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PUBLICATIONS
Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J. The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation. PloS one. 2021 May 11;16(5):e0250486.
Singhal NK, Sternbach S, Fleming S, Alkhayer K, Shelestak J, Popescu D, Weaver A, Clements R, Wasek B, Bottiglieri T, Freeman EJ, McDonough J. Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis. Epigenetics. 2020 Aug;15(8):871-886. doi: 10.1080/15592294.2020.1735075.
Hull V, Wang Y, Burns T, Zhang S, Sternbach S, McDonough J, Guo F, Pleasure D. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Ann Neurol. 2020 Mar;87(3):480-485. doi: 10.1002/ana.25674.
Mori T, Cukelj R, Prévôt ME, Ustunel S, Story A, Gao Y, Diabre K, McDonough JA, Freeman EJ, Hegmann E, Clements RJ. 3D Porous Liquid Crystal Elastomer Foams Supporting Long-term Neuronal Cultures. Macromol Rapid Commun. 2020 Mar;41(5):e1900585. doi: 10.1002/marc.201900585.
Singhal NK, Alkhayer K, Shelestak J, Clements R, Freeman E, McDonough J. Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity. Mol Neurobiol. 2018 Oct;55(10):8051-8058. doi:10.1007/s12035-018-0971-6
Popescu DC, Huang H, Singhal NK, Shriver L, McDonough J, Clements RJ, Freeman EJ. Vitamin K enhances the production of brain sulfatides during remyelination. PLoS One. 2018 Aug 27;13(8):e0203057. doi: 10.1371/journal.pone.0203057.
Singhal NK, Freeman E, Arning E, Wasek B, Clements R, Sheppard C, Blake P, Bottiglieri T, McDonough J. Dysregulation of methionine metabolism in multiple sclerosis. Neurochem Int. 2018 Jan;112:1-4. doi: 10.1016/j.neuint.2017.10.011
Singhal NK, Huang H, Li S, Clements R, Gadd J, Daniels A, Kooijman EE, Bannerman P, Burns T, Guo F, Pleasure D, Freeman E, Shriver L, McDonough J. The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition. Exp Brain Res. 2017 Jan;235(1):279-292. doi: 10.1007/s00221-016-4789-z
Brown N, Alkhayer K, Clements R, Singhal N, Gregory R, Azzam S, Li S, Freeman E, McDonough J. Neuronal Hemoglobin Expression and Its Relevance to Multiple Sclerosis Neuropathology. J Mol Neurosci. 2016 May;59(1):1-17. doi: 10.1007/s12031-015-0711-6
Singhal N K , Li S, Arning E, Alkhayer K, Clements R, Sarcyk Z, Dassanayake R S, Brasch N E, Freeman E J, Bottiglieri T, McDonough J. Changes in Methionine Metabolism and Histone H3 Trimethylation are Linked to Mitochondrial Defects in Multiple Sclerosis. J. Neurosci. 2015; 35, 15170 –15186. doi: 10.1523/JNEUROSCI.4349-14.2015
Li S, Clements R, Sulak M, Gregory R, Freeman E, McDonough J. Decreased NAA in Gray Matter is Correlated with Decreased Availability of Acetate in White Matter in Postmortem Multiple Sclerosis Cortex. Neurochem. Res. 2013;38, 2385-2396. doi: 10.1007/s11064-013-1151-8
Broadwater, L., Pandit, A., Clements, R., Azzam, S., Vadnal, J., Sulak, M., Yong, V.W., Freeman, E., Gregory, R., McDonough, J. Analysis of the mitochondrial proteome in multiple sclerosis cortex. Biochim. Biophys. Acta. 2011;1812, 630-641. doi: 10.1016/j.bbadis.2011.01.012.
Publications: Publications
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